4.5/5
2042 Ratings | About Ratings

David Markel, MD

Specialties

Knee, Fractures & Trauma, Hip, Infection

Languages

English
4.5/5
2042 Ratings | 332 Comments | About Ratings

Services & Specialties

Knee, Fractures & Trauma, Hip, Infection

Languages

English

Office Information

Novi Clinic

26750 Providence Pkwy
Suite 200
Novi, MI 48374
Main Number: 248.349.7015
Fax: 866.939.2673

Office Information

Biography

David C. Markel, MD is a nationally recognized orthopedic surgeon, researcher, and educator. He is board certified and fellowship-trained. He cares for patients with hip and knee pain using the most modern operative and non-operative techniques. He performs primary and revision hip and knee replacements and routinely treats complex cases, failed and poorly performing replacements and infections.

Dr. Markel completed a hip and knee reconstruction fellowship and was a Junior Attending Surgeon at the Hospital for Special Surgery, Weill Cornell Medical College in New York City. He was granted the opportunity to study orthopedic traumatology as an AO International Trauma Fellow in Bochum, Germany. Before fellowship training, Dr. Markel completed an orthopedic surgery residency, general surgery internship and received a medical degree from the University of Michigan in Ann Arbor. He obtained his bachelor’s degree from Kalamazoo College.

Dr. Markel is the Medical director for Orthopedic Surgery service line at St. John-Providence Hospital in Southfield, MI and Providence Park Hospital in Novi, MI. He is an Examiner for The American Board of Orthopedic Surgery, member of the Board and past Chair of the research committee for the American Association of Hip and Knee Surgeons, two time Past- President and current Board Member for the Michigan Orthopedic Society. He was inducted into The Knee Society, is a past member of the Board of Counselors and former Leadership Fellow for the American Academy of Orthopedic Surgery, and a former Member of the Board and past Chairman of the Education Committee for the Mid-America Orthopedic Association.

David C. Markel, MD is a nationally recognized orthopedic surgeon, researcher, and educator. He is board certified and fellowship-trained. He cares for patients with hip and knee pain using the most modern operative and non-operative techniques. He performs primary and revision hip and knee replacements and routinely treats complex cases, failed and poorly performing replacements and infections.

Dr. Markel completed a hip and knee reconstruction fellowship and was a Junior Attending Surgeon at the Hospital for Special Surgery, Weill Cornell Medical College in New York City. He was granted the opportunity to study orthopedic traumatology as an AO International Trauma Fellow in Bochum, Germany. Before fellowship training, Dr. Markel completed an orthopedic surgery residency, general surgery internship and received a medical degree from the University of Michigan in Ann Arbor. He obtained his bachelor’s degree from Kalamazoo College.

Dr. Markel is the Medical director for Orthopedic Surgery service line at St. John-Providence Hospital in Southfield, MI and Providence Park Hospital in Novi, MI. He is an Examiner for The American Board of Orthopedic Surgery, member of the Board and past Chair of the research committee for the American Association of Hip and Knee Surgeons, two time Past- President and current Board Member for the Michigan Orthopedic Society. He was inducted into The Knee Society, is a past member of the Board of Counselors and former Leadership Fellow for the American Academy of Orthopedic Surgery, and a former Member of the Board and past Chairman of the Education Committee for the Mid-America Orthopedic Association.

He was the Chair of the Northwest Detroit Orthopedic Residency Program and currently serves as a site director for the DMC-Wayne State University orthopedic residency program. He directs the research efforts in the orthopedic molecular biology laboratory at Providence Hospital. He maintains additional titles of Clinical Professor for the Department of Orthopedics at Wayne State University and Michigan State University. He is an Adjunct Professor in the Department of Bioengineering at Wayne State University and Adjunct Clinical Professor at Michigan State University and the American University of the Caribbean School of Medicine.

To date, he has authored over 90 peer-reviewed publications and three book chapters. He has received funding from several sources including a OREF program development grant, a new investigator grant, a VA research grant, an AAHKS research grant, and several resident development grants from the Orthopedic Research and Education Foundation. He routinely lectures at local, regional, national and internationally.

Procedures & Areas of Interest

  • Arthritis
  • Bursitis
  • Elbow Ligament Reconstruction
  • Fracture Care
  • Hip & Knee Instability
  • Hip Dislocation
  • Instability
  • Joint Replacement Infections
  • MAKO Robotic Arm-Assisted Joint
  • Partial Joint Replacement Surgery of the Knee
  • Replacement Surgery of the Knee
  • Reverse Joint Replacement Surgery of the Hip
  • Reverse Joint Replacement Surgery of the Knee
  • Sprains & Strains
  • Tendinitis
  • Total Joint Replacement Surgery of the Hip
  • Total Joint Replacement Surgery of the Knee

Fellowship

The Hospital for Special Surgery-Weill Cornell Medical College

Residency

University of Michigan

Internship

University of Michigan

Doctoral

University of Michigan

Undergraduate

Kalamazoo College

Board Certification

Board Certified

Accolades

  • 2017 – Best Research Paper Award: The British Hip Society
  • 2016 – HAP Paul Biomechanics Award, International Society for technology in Arthroplasty
  • 2016 – American Academy of Hip and Knee Surgeons, Best Poster Award Primary Knee
  • 2013 – Invited Member, The Knee Society
  • 2005-2008 – Orthopaedic Research and Education Foundation-Career Development Award
  • 2004-2005 – American Academy of Orthopedic Surgery Leadership Fellow
  • 2004-2005 – American Academy of Orthopaedic Surgery Leadership
  • 2003 – Invited Member: American Orthopaedic Association
  • 1998-1999 – Mid-America Orthopedic Society Traveling Fellow

Patient Satisfaction Reviews

The CORE Institute is focused on providing an exceptional patient care experience. To ensure that we are holding ourselves to the highest standards, we measure all aspects of patient satisfaction with the National Research Corporation, an independent patient satisfaction company. This service partnership provides the technology to display ratings on our physician profile pages, and all ratings are verified and submitted by actual patients.

Responses are measured on a scale of 1 to 5, with 5 being the best score.  submitted by patients as a reflection of their views and opinions. The resulting ratings are not directly endorsed by and do not necessarily reflect the views of The CORE Institute.

Overall 4.5 out of 5

Explained Understandably 4.6
Listened Carefully 4.6
Gave Understandable Answers 4.6
Knew Medical History 4.3
Showed Respect 4.6
Spent Enough Time 4.4

Research and Experience

Publications

Ren W, Song W, Yurgelevic S, Markel DC. Setting mechanism of a new injectable Dicalcium Phosphate Dihydrate (DCPD) forming cement. J Mech Behav Biomed Mater. 2018 Jan 4;79:226-234. doi: 10.1016/j.jmbbm.2017.12.032. [Epub ahead of print] PMID:29331590

Zhou Z, Seta J, Markel DC, Song W, Yurgelevic SM, Yu XW, Ren W. Release of vancomycin and tobramycin from polymethylmethacrylate cements impregnated with calcium polyphosphate hydrogel. J Biomed Mater Res B Appl Biomater. 2017 Dec 28. doi: 10.1002/jbm.b.34063. [Epub ahead of print] PubMed PMID: 29282858.

Markel DC, Allen MW, Hughes RE, Singal BM, Hallstrom BR. Quality Initiative Programs Can Decrease Total Joint Arthroplasty Transfusion Rates-A Multicenter Study Using the MARCQI Total Joint Registry Database. J Arthroplasty. 2017 Nov;32(11):3292-3297. doi: 10.1016/j.arth.2017.06.009. Epub 2017 Jun 13. PubMed PMID: 28697866.

Zarling BJ, Sikora-Klak J, Bergum C, Markel DC. How Do Preoperative Medications Influence Outcomes After Total Joint Arthroplasty? J Arthroplasty. 2017 Sep;32(9S):S259-S262. doi: 10.1016/j.arth.2017.04.031. Epub 2017 Apr 27. PubMed PMID: 28578845.

Song W, Seta J, Chen L, Bergum C, Zhou Z, Kanneganti P, Kast RE, Auner GW, Shen M, Markel DC, Ren W, Yu X. Doxycycline-loaded coaxial nanofiber coating of titanium implants enhances osseointegration and inhibits Staphylococcus aureus infection. Biomed Mater. 2017 Jul 5;12(4):045008. doi: 10.1088/1748-605X/aa6a26. PubMed PMID: 28357996.

Karek MR, Jackson NM, Flynn JC, Vaidya R, Markel DC. Elution Profiles of Two Methods of Antibiotic Tibial Nail Preparations. Orthopedics. 2017 May 1;40(3):e436-e442. doi: 10.3928/01477447-20170120-01. Epub 2017 Jan 31. PubMed PMID: 28135373.

Morris MR, Bergum C, Jackson N, Markel DC. Decreased Bacterial Adherence, Biofilm Formation, and Tissue Reactivity of Barbed Monofilament Suture in an In Vivo Contaminated Wound Model. J Arthroplasty. 2017 Apr;32(4):1272-1279. doi:

10.1016/j.arth.2016.11.010. Epub 2016 Nov 24. PubMed PMID: 28065625.

Sikora-Klak J, Zarling B, Bergum C, Flynn JC, Markel DC. The Effect of Comorbidities on Discharge Disposition and Readmission for Total Joint Arthroplasty Patients. J Arthroplasty. 2017 May;32(5):1414-1417. doi: 10.1016/j.arth.2016.11.035. Epub 2016 Nov 29. PubMed PMID: 28041771.

Sikora-Klak J, Gupta A, Bergum C, Zarling B, Markel DC. The Evaluation of Comorbidities Relative to Length of Stay for Total Joint Arthroplasty Patients. J Arthroplasty. 2017 Apr;32(4):1085-1088. doi: 10.1016/j.arth.2016.10.034. Epub 2016 Nov 16. PubMed PMID: 28012724.

Majewski RL, Zhang W, Ma X, Cui Z, Ren W, Markel DC. Bioencapsulation technologies in tissue engineering. J Appl Biomater Funct Mater. 2016 Nov 2;14(4):e395-e403. doi: 10.5301/jabfm.5000299. Review. PubMed PMID: 27716872; PubMed Central PMCID: PMC5623183.

Courtney PM, Markel DC. Arthroplasty Registries: Improving Clinical and Economic Outcomes. J Knee Surg. 2017 Jan;30(1):7-11. doi: 10.1055/s-0036-1593615. Epub 2016 Oct 24. PubMed PMID: 27776373.

Uchimura T, Foote AT, Markel DC, Ren W, Zeng L. The Chondroprotective Role of Erythromycin in a Murine Joint Destruction Model. Cartilage. 2016 Oct;7(4):373-87. doi: 10.1177/1947603516630787. Epub 2016 Feb 17. PubMed PMID:

27688845; PubMed Central PMCID: PMC5029567.

Courtney PM, Huddleston JI, Iorio R, Markel DC. Socioeconomic Risk Adjustment Models for Reimbursement Are Necessary in Primary Total Joint Arthroplasty. J Arthroplasty. 2017 Jan;32(1):1-5. doi: 10.1016/j.arth.2016.06.050. Epub 2016 Jul 16. PubMed PMID: 27506724.

Zarling BJ, Yokhana SS, Herzog DT, Markel DC. Preoperative and Postoperative Opiate Use by the Arthroplasty Patient. J Arthroplasty. 2016 Oct;31(10):2081-4. doi: 10.1016/j.arth.2016.03.061. Epub 2016 Apr 12. PubMed PMID: 27161903.

Chen L, Song W, Markel DC, Shi T, Muzik O, Matthew H, Ren W. Flow perfusion culture of MC3T3-E1 osteogenic cells on gradient calcium polyphosphate scaffolds with different pore sizes. J Biomater Appl. 2016 Feb;30(7):908-18. doi: 10.1177/0885328215608335. Epub 2015 Dec 15. PubMed PMID: 26675750.

Cook GE, Markel DC, Ren W, Webb LX, McKee MD, Schemitsch EH. Infection in Orthopaedics. J Orthop Trauma. 2015 Dec;29 Suppl 12:S19-23. doi: 10.1097/BOT.0000000000000461. Review. PubMed PMID: 26584261.

Vigdorchik JM, Riesgo AM, Lincoln D, Markel DC. Pulmonary Findings on Computed Tomography in Asymptomatic Total Joint Arthroplasty Patients. J Knee Surg. 2016 Aug;29(6):478-81. doi: 10.1055/s-0035-1566734. Epub 2015 Nov 9. PubMed PMID: 26551068.

Allen MW, Zappa NM, Markel DC. Erratum to: Can an Arthroplasty Registry Help Decrease Transfusions in Primary Total Joint Replacement? A Quality Initiative. Clin Orthop Relat Res. 2016 Jan;474(1):279. doi: 10.1007/s11999-015-4557-6. PubMed PMID: 26452747; PubMed Central PMCID: PMC4686486.

Markel DC, Allen MW, Zappa NM. Can an Arthroplasty Registry Help Decrease Transfusions in Primary Total Joint Replacement? A Quality Initiative. Clin Orthop Relat Res. 2016 Jan;474(1):126-31. doi: 10.1007/s11999-015-4470-z. Erratum in: Clin Orthop Relat Res. 2016 Jan;474(1):279. PubMed PMID: 26215083; PubMed Central PMCID: PMC4686507.

Walsh CP, Hubbard JC, Nessler JP, Markel DC. MRI Findings Associated with Recalled Modular Femoral Neck Rejuvenate and ABG Implants. J Arthroplasty. 2015 Nov;30(11):2021-6. doi: 10.1016/j.arth.2015.05.021. Epub 2015 May 19. PubMed PMID: 26122109.

Vigdorchik JM, D’Apuzzo MR, Markel DC, Malkani AL, Raterman S, Sharpe KP, Cornell CN, Westrich GH. Lack of early dislocation following total hip arthroplasty with a new dual mobility acetabular design. Hip Int. 2015 Jan-Feb;25(1):34-8. doi: 10.5301/hipint.5000186. Epub 2015 Feb 3. PubMed PMID: 25655740.

Walsh CP, Hubbard JC, Nessler JP, Markel DC. Revision of Recalled Modular Neck Rejuvenate and ABG Femoral Implants. J Arthroplasty. 2015 May;30(5):822-6. doi: 10.1016/j.arth.2014.12.002. Epub 2014 Dec 5. PubMed PMID: 25573180.

Loving L, Herrera L, Banerjee S, Heffernan C, Nevelos J, Markel DC, Mont MA. Dual mobility bearings withstand loading from steeper cup-inclinations without substantial wear. J Orthop Res. 2015 Mar;33(3):398-404. doi: 10.1002/jor.22774. Epub 2014 Nov 24. Erratum in: J Orthop Res. 2017 Jun;35(6):1348. PubMed PMID: 25421305.

Shen Y, Wang W, Li X, Markel DC, Ren W. Mitigative effect of erythromycin on PMMA challenged preosteoblastic MC3T3-E1 cells. ScientificWorldJournal. 2014;2014:107196. doi: 10.1155/2014/107196. Epub 2014 Jun 3. PubMed PMID: 25110723; PubMed Central PMCID: PMC4119688.

Ren W, Jackson N, Song W, Shi T, Flynn JC, Markel DC. Implant wear induced inflammation is mitigated in CX3CR1(-/-) mice. J Orthop Res. 2014 Aug;32(8):1037-43. doi: 10.1002/jor.22625. Epub 2014 Apr 3. PubMed PMID: 24700421.

Jaafar S, Vigdorchik J, Markel DC. Drain technique in elective total joint arthroplasty. Orthopedics. 2014 Jan;37(1):37-9. PubMed PMID: 24683648.

Markel DC, Jackson NM, Esquivel AO, Ren W, Flynn JC. Immunological response to bolus versus multiple injections of hylan G-F 20 (Synvisc) in a murine biocompatibility model. J Biomed Mater Res B Appl Biomater. 2014 Oct;102(7):1375-80. doi: 10.1002/jbm.b.33116. Epub 2014 Feb 6. PubMed PMID: 24500880.

Heffernan C, Banerjee S, Nevelos J, Macintyre J, Issa K, Markel DC, Mont MA. Does dual-mobility cup geometry affect posterior horizontal dislocation distance? Clin Orthop Relat Res. 2014 May;472(5):1535-44. doi: 10.1007/s11999-014-3469-1. Epub 2014 Jan 24. PubMed PMID: 24464508; PubMed Central PMCID: PMC3971207.

Markel DC, Sauer PJ, Blasier RB. Is a Physician “Provider Tax” the Solution to Michigan’s Medicaid Woes? HSS J. 2013 Oct;9(3):257-63. doi: 10.1007/s11420-013-9348-6. Epub 2013 Aug 29. Review. PubMed PMID: 24426877; PubMed Central PMCID: PMC3772163.

Ren WP, Song W, Esquivel AO, Jackson NM, Nelson M, Flynn JC, Markel DC. Effect of erythromycin-doped calcium polyphosphate scaffold composite in a mouse pouch infection model. J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1140-7. doi: 10.1002/jbm.b.33095. Epub 2013 Dec 18. PubMed PMID: 24347324.

Song W, Yu X, Markel DC, Shi T, Ren W. Coaxial PCL/PVA electrospun nanofibers: osseointegration enhancer and controlled drug release device. Biofabrication. 2013 Sep;5(3):035006. doi: 10.1088/1758-5082/5/3/035006. Epub 2013 Jun 25. PubMed PMID: 23799653.

Kesto WK, Esquivel AO, Markel DC. Shear Force at Failure and Stiffness of All-Inside Meniscal Repair Devices. J Knee Surg. 2013 Jun 11. [Epub ahead of print] PubMed PMID: 23760666.

Keyes BJ, Markel DC, Meneghini RM. Evaluation of limb alignment, component positioning, and function in primary total knee arthroplasty using a pinless navigation technique compared with conventional methods. J Knee Surg. 2013 Apr;26(2):127-32. doi: 10.1055/s-0032-1319788. Epub 2012 Jul 13. PubMed PMID: 23288760.

Lee RK, Nevelos J, Vigdorchik J, Markel DC. Bearing surfaces for hip arthroplasty – is metal-on-metal a passing fancy? Surg Technol Int. 2012 Dec;22:243-9. PubMed PMID: 23065801.

Knesek D, Peterson TC, Markel DC. Thromboembolic prophylaxis in total joint arthroplasty. Thrombosis. 2012;2012:837896. doi: 10.1155/2012/837896. Epub 2012 Sep 16. PubMed PMID: 23029611; PubMed Central PMCID: PMC3458274.

Nevelos J, Johnson A, Heffernan C, Macintyre J, Markel DC, Mont MA. What factors affect posterior dislocation distance in THA? Clin Orthop Relat Res. 2013 Feb;471(2):519-26. doi: 10.1007/s11999-012-2559-1. PubMed PMID: 22956235; PubMed

Central PMCID: PMC3549146.

Song W, Markel DC, Jin X, Shi T, Ren W. Poly(vinyl alcohol)/collagen/hydroxyapatite hydrogel: properties and in vitro cellular

response. J Biomed Mater Res A. 2012 Nov;100(11):3071-9. doi: 10.1002/jbm.a.34240. Epub 2012 Jun 26. PubMed PMID: 22733675.

Ren W, Muzik O, Jackson N, Khoury B, Shi T, Flynn JC, Chakraborty P, Markel DC. Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models. Nucl Med Commun. 2012 Jul;33(7):747-56. doi: 10.1097/MNM.0b013e328353bbd3. PubMed PMID: 22513886.

Song W, Markel DC, Wang S, Shi T, Mao G, Ren W. Electrospun polyvinyl alcohol-collagen-hydroxyapatite nanofibers: a biomimetic extracellular matrix for osteoblastic cells. Nanotechnology. 2012 Mar 23;23(11):115101. doi: 10.1088/0957-4484/23/11/115101. Epub 2012 Feb 28. PubMed PMID: 22370251.

Markel DC, Guthrie ST, Wu B, Song Z, Wooley PH. Characterization of the inflammatory response to four commercial bone graft substitutes using a murine biocompatibility model. J Inflamm Res. 2012;5:13-8. doi: 10.2147/JIR.S21411. Epub 2012 Jan 18. PubMed PMID: 22334792; PubMed Central PMCID: PMC3278258.

Song W, Yu X, Wang S, Blasier R, Markel DC, Mao G, Shi T, Ren W. Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application. Int J Nanomedicine. 2011;6:3173-86. doi: 10.2147/IJN.S23530. Epub 2011 Dec 8. PubMed PMID: 22228990; PubMed Central PMCID: PMC3252670.

Ren W, Zhang R, Wu B, Wooley PH, Hawkins M, Markel DC. Effects of SU5416 and a vascular endothelial growth factor neutralizing antibody on wear debris-induced inflammatory osteolysis in a mouse model. J Inflamm Res. 2011;4:29-38. doi:

10.2147/JIR.S16232. Epub 2011 Mar 2. PubMed PMID: 22096367; PubMed Central PMCID: PMC3218747.

Shen Y, Wang W, Li X, Liu Z, Markel DC, Ren W. Impacts of age and gender on bone marrow profiles of BMP7, BMPRs and Stro-1⁺ cells in patients with total hip replacement. Int Orthop. 2012 Apr;36(4):879-86. doi: 10.1007/s00264-011-1370-z. Epub 2011 Nov 3. PubMed PMID: 22048752; PubMed Central PMCID: PMC3311791.

Song W, Ren W, Wan C, Esquivel AO, Shi T, Blasier R, Markel DC. A novel strontium-doped calcium polyphosphate/erythromycin/poly(vinyl alcohol) composite for bone tissue engineering. J Biomed Mater Res A. 2011 Sep 1;98(3):359-71. doi: 10.1002/jbm.a.33127. Epub 2011 May 27. PubMed PMID: 21626667.

Ren W, Markel DC. Emerging ideas: can erythromycin reduce the risk of aseptic loosening? Clin Orthop Relat Res. 2011 Aug;469(8):2399-403. doi: 10.1007/s11999-011-1918-7. Epub 2011 May 17. PubMed PMID: 21584820; PubMed Central PMCID: PMC3126949.

Mulder AA, Esquivel AO, Bak SF, Lincoln DR, Markel DC. Novel angle measurements for assessment of shoulder location using the scapular y radiograph. Orthopedics. 2011 May;34(5):367. doi: 10.3928/01477447-20110317-15. PubMed PMID: 21553740.

Khoury JI, Malkani AL, Adler EM, Markel DC. Constrained acetabular liners cemented into cages during total hip revision arthroplasty. J Arthroplasty. 2010 Sep;25(6):901-5. doi: 10.1016/j.arth.2009.08.012. PubMed PMID: 20620017.

Ren W, Zhang R, Hawkins M, Shi T, Markel DC. Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis. Inflamm Res. 2010 Dec;59(12):1091-7. doi: 10.1007/s00011-010-0229-x. Epub 2010 Jul 6. PubMed PMID: 20607583.

Molli RG, Anderson KC, Buehler KC, Markel DC. Computer-assisted navigation software advancements improve the accuracy of total knee arthroplasty. J Arthroplasty. 2011 Apr;26(3):432-8. doi: 10.1016/j.arth.2010.01.002. Epub 2010 Mar 23. PubMed PMID: 20334996.

Markel DC, York S, Liston MJ Jr, Flynn JC, Barnes CL, Davis CM 3rd; AAHKS Research Committee. Venous thromboembolism: management by American Association of Hip and Knee Surgeons. J Arthroplasty. 2010 Jan;25(1):3-9.e1-2. doi: 10.1016/j.arth.2009.07.021. Epub 2009 Oct 17. PubMed PMID: 19837560.

Schmidig G, Patel A, Liepins I, Thakore M, Markel DC. The effects of acetabular shell deformation and liner thickness on frictional torque in ultrahigh-molecular-weight polyethylene acetabular bearings. J Arthroplasty. 2010 Jun;25(4):644-53. doi: 10.1016/j.arth.2009.03.020. Epub 2009 Jun 2. PubMed PMID: 19493649.

Zhang K, Jia TH, McQueen D, Gong WM, Markel DC, Wooley PH, Yang SY. Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation. Inflamm Res. 2009 Dec;58(12):837-44. doi: 10.1007/s00011-009-0051-5. Epub 2009 May 30. PubMed PMID: 19484187; PubMed Central PMCID: PMC2863076.

Markel DC, Zhang R, Shi T, Hawkins M, Ren W. Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis. Inflamm Res. 2009 Jul;58(7):413-21. doi: 10.1007/s00011-009-0007-9. Epub 2009 Mar 5. PubMed PMID: 19262986.

Markel DC, Mendelson SD, Yudelev M, Essner A, Yau SS, Wang A. The effect of neutron radiation on conventional and highly cross-linked ultrahigh-molecular-weight polyethylene wear. J Arthroplasty. 2008 Aug;23(5):732-5. doi: 10.1016/j.arth.2007.06.011. Epub 2008 Jan 22. PubMed PMID: 18534543.

Najarian BC, Kilgore JE, Markel DC. Evaluation of component positioning in primary total hip arthroplasty using an imageless navigation device compared with traditional methods. J Arthroplasty. 2009 Jan;24(1):15-21. doi: 10.1016/j.arth.2008.01.004. Epub 2008 Apr 3. PubMed PMID: 18534411.

Ren W, Markel DC, Schwendener R, Ding Y, Wu B, Wooley PH. Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. J Biomed Mater Res A. 2008 Jun 15;85(4):1043-51. PubMed PMID: 17937417.

Markel DC, Doerr T, Lincoln D, Bass NF. Observational study on intrathecal and peridural changes after routine spinal and epidural anesthesia in patients undergoing total joint arthroplasty. J Arthroplasty. 2007 Sep;22(6):844-8. Epub 2007 Apr 20. PubMed PMID: 17826275.

Walter F, Haynes MB, Markel DC. A randomized prospective study evaluating the effect of patellar eversion on the early functional outcomes in primary total knee arthroplasty. J Arthroplasty. 2007 Jun;22(4):509-14. Epub 2007 Mar 28.

PubMed PMID: 17562406.

Markel DC, Andary JL, Pagano P, Nasser S. Assessment of acetabular version by plain radiograph. Am J Orthop (Belle Mead NJ). 2007 Jan;36(1):39-41. PubMed PMID: 17460875.

Ren W, Zhang R, Markel DC, Wu B, Peng X, Hawkins M, Wooley PH. Blockade of vascular endothelial growth factor activity suppresses wear debris-induced inflammatory osteolysis. J Rheumatol. 2007 Jan;34(1):27-35. PubMed PMID:

17216676.

Ottaviani RA, Wooley P, Song Z, Markel DC. Inflammatory and immunological responses to hyaluronan preparations. Study of a murine biocompatibility model. J Bone Joint Surg Am. 2007 Jan;89(1):148-57. PubMed PMID: 17200322.

Walter FL, Bass N, Bock G, Markel DC. Success of clinical pathways for total joint arthroplasty in a community hospital. Clin Orthop Relat Res. 2007 Apr;457:133-7. PubMed PMID: 17065839.

Kansara D, Markel DC. The effect of posterior tibial slope on range of motion after total knee arthroplasty. J Arthroplasty. 2006 Sep;21(6):809-13. PubMed PMID: 16950031.

Ren WP, Markel DC, Zhang R, Peng X, Wu B, Monica H, Wooley PH. Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials. 2006 Oct;27(30):5161-9. Epub 2006 Jun 30. PubMed PMID: 16814378.

Anderson KC, Buehler KC, Markel DC. Computer assisted navigation in total knee arthroplasty: comparison with conventional methods. J Arthroplasty. 2005 Oct;20(7 Suppl 3):132-8. PubMed PMID: 16214014.

Markel DC, Sutton K. Unicompartmental knee arthroplasty: troubleshooting implant positioning and technical failures. J Knee Surg. 2005 Apr;18(2):96-101. Review. PubMed PMID: 15915829.

Yang SY, Nasser S, Markel DC, Robbins PD, Wooley PH. Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor. J Bone Joint Surg Am. 2005 May;87(5):1088-97.

PubMed PMID: 15866974.

Grutter PW, Markel DC. Simple techniques for passing suture through bone. Am J Orthop (Belle Mead NJ). 2005 Jan;34(1):47-8. PubMed PMID: 15707140.

Markel DC, Critchfield J, Chaffin A, Wooley PH, Grimm MJ. Cement pressurization after provisional repair of femoral cortical defects. Am J Orthop (Belle Mead NJ). 2003 May;32(5):229-33. PubMed PMID: 12772873.

Markel DC, Morris GD. Effect of external sequential compression devices on femoral venous blood flow. J South Orthop Assoc. 2002 Spring;11(1):2-9; quiz 10. PubMed PMID: 12741580.

Shapiro GS, Weiland DE, Markel DC, Padgett DE, Sculco TP, Pellicci PM. The use of a constrained acetabular component for recurrent dislocation. J Arthroplasty. 2003 Apr;18(3):250-8. PubMed PMID: 12728414.

Fisher SR, Markel DC, Koman JD, Atkinson TS. Pull-out and shear failure strengths of arthroscopic meniscal repair systems. Knee Surg Sports Traumatol Arthrosc. 2002 Sep;10(5):294-9. Epub 2002 Jun 5. PubMed PMID: 12355304.

Markel DC, Hoard DB, Porretta CA. Cemented total hip arthroplasty with

Boneloc bone cement. J South Orthop Assoc. 2001 Winter;10(4):202-8. PubMed PMID:

12132818.

Markel DC, Hora N, Grimm M. Press-fit stability of uncemented hemispheric acetabular components: a comparison of three porous coating systems. Int Orthop. 2002;26(2):72-5. PubMed PMID: 12078880; PubMed Central PMCID: PMC3620875.

Saleem A, Markel DC. Fatal pulmonary embolus after shoulder arthroplasty. J Arthroplasty. 2001 Apr;16(3):400-3. PubMed PMID: 11307142.

Markel DC, Blasier RB. Use of a reciprocating rasp as an adjunct to open acromioplasty. Am J Orthop (Belle Mead NJ). 2001 Jan;30(1):72. PubMed PMID: 11198834.

Walper JJ, Markel DC. Upper extremity deep venous thrombosis leading to pulmonary embolism after total hip arthroplasty. J Arthroplasty. 2001 Jan;16(1):124-7. PubMed PMID: 11172283.

Hora N, Markel DC, Haynes A, Grimm MJ. Biomechanical analysis of supracondylar femoral fractures fixed with modern retrograde intramedullary nails. J Orthop Trauma. 1999 Nov;13(8):539-44. PubMed PMID: 10714779.

Jacobs MJ, Markel DC. Geriatric intertrochanteric hip fractures: an economic analysis. Am J Orthop (Belle Mead NJ). 1999 Oct;28(10):573-6. PubMed PMID: 10541143.

Nasser S, Markel DC. Inexpensive methods of repairing cortical defects in cemented total joint replacement. J Arthroplasty. 1999 Jun;14(4):514-6. PubMed PMID: 10428236.

Markel DC, Femino JE, Farkas P, Markel SF. Analysis of lower extremity embolic material after total knee arthroplasty in a canine model. J Arthroplasty. 1999 Feb;14(2):227-32. PubMed PMID: 10065732.

Markel DC, Urquhart B, Derkowska I, Salvati EA, Sharrock NE. Effect of epidural analgesia on venous blood flow after hip arthroplasty. Clin Orthop Relat Res. 1997 Jan;(334):168-74. PubMed PMID: 9005910.

Markel DC, Luessenhop CP, Windsor RE, Sculco TA. Arthroscopic treatment of peripatellar fibrosis after total knee arthroplasty. J Arthroplasty. 1996 Apr;11(3):293-7. PubMed PMID: 8713909.

Markel DC, Miskovsky C, Sculco TP, Pellicci PM, Salvati EA. Core decompression for osteonecrosis of the femoral head. Clin Orthop Relat Res. 1996 Feb;(323):226-33. PubMed PMID: 8625585.

Markel DC, Huo MH, Katkin PD, Salvati EA. Use of cemented all-polyethylene and metal-backed acetabular components in total hip arthroplasty. A comparative study. J Arthroplasty. 1995 Nov;10 Suppl:S1-7. PubMed PMID: 8776049.

Markel DC, Graziano GP. A comparison study of treatment of thoracolumbar fractures using the ACE Posterior Segmental Fixator and Cotrel-Dubousset instrumentation. Orthopedics. 1995 Jul;18(7):679-86. PubMed PMID: 7479408.

Markel DC, Blasier RB. Bilateral anterior dislocation of the shoulders with greater tuberosity fractures. Orthopedics. 1994 Oct;17(10):945-9. PubMed PMID: 7824397.

Markel DC, Donley BG, Blasier RB. Percutaneous intramedullary pinning of proximal humeral fractures. Orthop Rev. 1994 Aug;23(8):667-71. PubMed PMID: 7997350.

Markel DC, Neumann KU, Steinau HU. Appropriate techniques for musculoskeletal tumor biopsy. Orthop Rev. 1994 Feb;23(2):176-80. PubMed PMID: 8196978.

Markel DC, Stubbs BT. Simple surgical techniques to protect the soft tissues during total knee arthroplasty. Orthop Rev. 1993 Jun;22(6):743-7. PubMed PMID: 8351179.

Markel DC, Raskas DS, Graziano GP. A case of traumatic spino-pelvic dissociation. J Orthop Trauma. 1993;7(6):562-6. PubMed PMID: 8308611.

Markel DC, Blasier RB, Edmunds MR. Technical tips for the fixation of supracondylar femur fractures with the sliding screw-plate device. Orthop Rev. 1992 Oct;21(10):1247-50. PubMed PMID: 1437252.

Markel DC, Graziano GP. Fracture of the S1 vertebral body in a patient with ankylosing spondylitis. J Spinal Disord. 1992 Jun;5(2):222-6. PubMed PMID: 1606383.

Publications (Non-Referred Journals)

D.C. Markel, “The Influence of Technique, Bearings and Implant Design on TJA.” Orthopaedic Today. 2011. Mar:13-15.

D.C. Markel and M. Kester, “High Performance Arthroplasty: What is it and Why Do We Need It.” Seminars in Arthroplasty. 2004. 15(3):171-174.

D.C. Markel and J. Horton, “The Role of Electrical Stimulation, Bone Morphogenic Protein, and Future Directions in Osteonecrosis of the Femoral Head.” Seminars in Arthroplasty. 2004. 15(3):171-174.

D.C. Markel, A. Wang, M. Poggie, M. Kester, “Mechanical Properties and Fatigue Performance of Crosslinked Polyethylene in Total Knee Applications.” Seminars in Arthroplasty. 2003. 14(4):222-231.

D.C. Markel, B. Kintz, “Insurance for Those Who Need Assurance.” Resident and Staff Physician. 2001. 47(10):52-55.

D.C. Markel, W.E. Schwartz, “Investments 101: A Tutorial for Basic Investments.” Resident and Staff Physician. 1999. 45(9):52-54.

Book Chapters

D.C. Markel and G. Golladay, “Revision for Instability…Options to Consider in Challenging Cases” in Fundamentals of Revision Hip Arthroplasty, David Jacofsky and Anthony Hedley Ed., Slack Inc (In Press)

D.C. Markel and C. McAllister, “Unicompartmental Knee Arthroplasty” in Arlen D. Hanssen and W. Norman Scott, Ed. Total Knee Replacement. Philadelphia, USA. Sauders Elsevier 2009. Section 1:3-24.

D.C. Markel, “Primary and Revision Arthroplasty of the Knee” In Freiberg, Andrew A. M.D., Ed. The Radiology of Orthopaedic Implants: An Atlas of Techniques and Assessment. St. Louis, USA. Mosby Books, Inc. 2001. Ch. 10:157-181.

Published Abstracts

Yokhana S, Bergum C, Markel DC “Tibial Component Failure in Total Knee Arthroplasty: A Unique Pattern of Failure” The Bone and Joint Journal. 27 March 2017 Online vol. 99-B no. SUPP 6 109

Karek MR, Jackson NM, Flynn JC, Vaidya R, Markel DC “Elution Profiles of Two Methods of Antibiotic Tibial Nail Preparations,” Orthopedics. 2017 Jan 30:1-7. doi: 10.3928/01477447-20170120-01. [Epub ahead of print]

Courtney PM, Huddleston JI, Iorio R, Markel DC “Socioeconomic Risk Adjustments Models for Reimbursement Are necessary in Primarily Total Joint Arthroplasty,” J Arthroplasty. 2017 Jan;32(1):1-5. doi: 10.1016/j.arth.2016.06.050. Epub 2016 Jul 16.

Sikora-Klak, J, Zarling B, Bergum C, Flynn JC, Markel DC, “The Effect of Comorbidities on Discharge Disposition and Readmission for Total Joint Arthroplasty Patients” J Arthroplasty. 2016 Nov 29. pii: S0883-5403(16)30835-X. doi: 10.1016/j.arth.2016.11.035 [Epub ahead of print]

C. Heffernan, J. MacIntyre, D.C. Markel, M. Mont, “The Influence of Dual Mobility Cup design on Posterior Horizontal dislocation distance in Common sizes of THR,” ORTHOPEDIC RESEARCH SOCIETY. 2013.

34:online.

W. Ren, R. Blasier, T. Shi, D.C. Markel, “Inhibitory Effect of Oral Erythromycin on Expression of CX3CR1/CX3CL1 in Periprosthetic Tissues.” Orthopaedic Transactions. 2009. 34:online.

H.N. Hao, N. Abdel-Haq, W. Ren, D.C. Markel, H. Pierre-Jacques, L. Morawa, “Wear Debris Particles Promote Bone Marrow Stromal Cells to Differentiate Into Osteoclast: A Mechanism of Orthopaedic Particles Related Osteolysis.” Orthopaedic Transactions. 2009. 34:online.

W. Ren, R. Zhang, M. Hawkins, T. Shi, P. Wooley, D.C. Markel, “Effects of Local Delivery of Erythromycin on Particle-Induced Osteolysis in a Rat Model.” Orthopaedic Transactions. 2009. 34:online.

D.C. Markel, T. Shi, W. Ren, “Expression of CX3CR1/CX3CL1 and PMMA- Induced Monocyte Trafficking.” Orthopaedic Transactions. 2009. 34:online.

W. Ren, Y. Ding, B. Chen, L. Li, D.C. Markel, “Role(s) of Twist in RANKL/RANK Signaling-Mediated Osteoclastogenesis.” Orthopaedic Transactions. 2009. 34:online.

W. Ren, D.C. Markel, X. Peng, T. Shi, P. Wooley, R. Blasier, “Effect of Oral Erythromycin Therapy in Patients with Aseptic Loosening.” Orthopaedic Transactions. 2008. 33:online.

K. Zhang, T. Jia, D.Z. Yin, T. Zhang, D.C. Markel, P. Wooley, S.Y. Yang, “A SCID-HU Chimera Model with Peripheral Blood Monocytes Transfusion for Osteolytic Prosthesis Failure.” Orthopaedic Transactions. 2008. 33:online.

D.C. Markel, J. Day, R. Siskey, I. Liepins, S. Kurtz, K. Ong, “Deformation of Metal-Backed Acetabular Components and the Impact of Liner Thickness in a Cadaveric Model.” Orthopaedic Transactions. 2008. 33:online.

G. Schmidig, A. Patel, I. Liepins, M. Thakore, D.C. Markel, “Effects of Acetabular Shell Deformation and Liner Thickness on Frictional Torque in Polyethylene Acetabular Bearings.” Orthopaedic Transactions. 2008. 33:online.

G. Schmidig, A. Patel, I. Liepins, M. Thakore, D.C. Markel, “The Effect of Acetabular Shell Deformation on Frictional Torque.” Orthopaedic Transactions. 2008. 33:online.

K. Ong, S. Rundell, I. Liepens, R. Laurent, D.C. Markel, S. Kurtz, “Biomechanical Evaluation of Acetabular Component Polyethylene Streses, Fracture Risk, and Wear Rate During Press-Fit Implantation.” Orthopaedic Transactions. 2008. 33:online.

W. Ren, T. Shi, R. Zhang, M. Hawkins, D.C. Markel, “Using Peri-ApatiteTM Coated Titanium Pin as a Carrier for Erythromycin.” Orthopaedic Transactions. 2008. 33:online.

D.C. Markel, W. Ren, R. Zhang, M. Hawkins, Y. Ding, P. Wooley, “VEGF Inhibitor Reduces UHMWPE Particle-Induced Inflammatory Osteolysis Through Targeting on VEGF/FLT-1 Signaling in a Mouse Model.”

Orthopaedic Transactions. 2008. 33:online.

W. Ren, D.C. Markel, M. Hawkins, R. Zhang, B. Wu, P. Wooley, “Therapeutic Effects of Erythromycin on UHMWPE Particle-Induced Inflammatory Osteolysis Through Modulation of VEGF/FLT-1 Gene Activation in a Mouse Model.” Orthopaedic Transactions. 2008. 33:online.

D. Pelinkovic, H. Hao, P. Pazomino, D.C. Markel, P. Wooley, “TLR-4 Expression in Intervertebral Disc Tissue: A Possible Link to Degenerative Disc Disease.” Orthopaedic Transactions. 2006. 31:online.

W. Ren, D.C. Markel, R. Zhang, X. Peng, B. Wu, M. Hawkins, P. Wooley, “VEGF/FLT-1 Signaling in UHMWPE Particle-Induced Inflammatory Osteoclastogenesis.” Orthopaedic Transactions. 2006. 31:online.

W. Ren, D.C. Markel, R. Zhang, B. Wu, X. Peng, L. Mayton, D. Yu, M. Hawkins, P. Wooley, “Effects of Locally Applied Vascular Endothelial Growth Factor (VEGF) and VEGF Inhibitor in a Mouse Model of Wear Debris Induced Inflammatory Osteolysis.” Orthopaedic Transactions. 2005. 30:online.

W. Ren, B. Wu, X. Peng, L. Mayton, B. Geer, D.C. Markel, P. Wooley, “Quantification of Implanted Bone Destruction in Mice by Micro-Computed Tomography (Micro CT).” Orthopaedic Transactions. 2005. 30:online.

A. Mendelson, Z. Song, S. Nasser, D.C. Markel, P. Wooley, “The CD69 Cell Activation Antigen is Elevated During the Response to Biomaterials on B Lymphocytes from Arthroplasty Patients.” Orthopaedic Transactions 2004. 29:online.

W. Ren, B. Wu, L. Mayton, X. Peng, D.C. Markel, P. Wooley, “Quantification of Implanted Bone Destruction In Mice by Micro-Computed Tomogrophy (Micro CT).” ORTHOP Orthopaedic Transactions. 2004. Online.

R. W. Klein, M. Bushelow, D.C. Markel, M. A. Kester, “Fatigue Performance of Highly Cross-Linked Patella Components.” Orthopaedic Transactions. 2003. 28:online.

S. D. Mendelson, P. Wooley, D. C. Markel,“The Effect of Hyaluronic Acid on a Rabbit Model of Full Thickness Articular Cartilage Repair Following Acute Injury.” Orthopaedic Transactions. 2003. 28:online.

D.B. Hoard, D.C. Markel, C.A. Porretta, “Cemented Total Hip Arthroplasty With Boneloc Bone Cement.” J. South Orthopaedic Association. 2001. 10(4):202-208.

D.C. Markel, N. Hora, A. Haynes, M. Grimm, “A Biomechanical Comparison of the Fixation of Supracondylar Femur Fractures With Modern Retrograde Supracondylar Femoral Nails.” Orthopaedic Transactions 1998-1999. 22(1):234.

D.C. Markel, N. Hora, M. Milosic, M. Grimm, “Initial Press-Fit Stability of Uncemented Hemispheric Coated Acetabular Components: A Biomechanical Comparison of Three Surface Preparations.” Orthopaedic Transactions. 1998-1999. 22(1):194.

D.C. Markel, J. Femino, P. Farkas, S.F. Markel, M.D., “Analysis of Embolic Debris During Total Knee Athroplasty in a Canine Model.” Orthopaedic Transactions. 1997-1998. 21;963-964.

D.C. Markel, B. Urquart, I. Derkowska, E. Salvati, N. Sharrock, “The Effect of Epidural Analgesia on Lower Extremity Blood Flow After Hip Arthroplasty.” Orthopaedic Transactions. 1996-1997. 20:848.

J. M. Koman, D.C. Markel, “The Costs of In Hospital Orthopaedic Injuries.” Orthopaedic Transactions. 1996-1997. 20:849.

K. Sidhu, G. Graziano, D.C. Markel, M. Greenfield, “Results of Fixation of Thoracic and Lumbar Burst Fractures With The Olerud Short Segment Pedicle Screw Fixator.” Orthopaedic Transactions. 1995-1996. 20:775.

D.C. Markel, D. Green, D. Padgett, P.D. Wilson, “A Clinical Evaluation of the “Plamp,” A Hooked PlateClamp Trochanteric Fixation Device.” Orthopaedic Transactions. 1995. 19:548.

D.C. Markel, D. Wolff, P.M. Pellicci, “The Use of a Constrained Acetabular Component in Cases of Recurrent Prosthetic Hip Dislocation and Instability at the Time of Revision Surgery.” Orthopaedic Transactions S. 1995. 19:567.

D.C. Markel, C. Miskovsky, T.P. Sculco, P.M. Pellicci, E.A. Sa

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